Please use this identifier to cite or link to this item: http://ddms.usim.edu.my:80/jspui/handle/123456789/8397
Title: Risk Factors Associated with Unconjugated Neonatal Hyperbilirubinemia in Malaysian Neonates
Authors: Feiliang, Wong,
NemYun, Boo,
Ainoon, Othman,
Keywords: Keratinocyte-Like Cells
Embryonic Stem-Cells
Epithelial-Cells
Epidermal Morphogenesis
Gene-Expression
In-Vitro
Differentiation
Membrane
Issue Date: 2013
Publisher: Oxford Univ Press
Abstract: Methods: A prospective study was conducted to investigate the effects of glucose-6-phosphate dehydrogenase (G6PD) mutation, variant uridine diphosphate glucuronosyltransferase UGT1A1 gene and hepatic organic anion transporter protein (OATP2) gene on a group of neonates. Hyperbilirubinemia was defined as a total serum bilirubin level of epsilon 250 mu mol/l. Results: Of 318 neonates, 52 (16.4%) had hyperbilirubinemia. The incidence of G6PD mutation was 5.4% (15/280) among these infants. The incidence of G6PD mutation was significantly higher in the male neonates with hyperbilirubinemia (7.8%) when compared with the normal male neonates without hyperbilirubinemia (1.8%; p = 0.03). Logistic regression analysis showed that the significant risk factors for neonatal hyperbilirubinemia were Malay ethnicity [adjusted odds ratio (OR), 2.77; 95% confidence interval (CI): 1.31-5.86; p = 0.007] and G6PD mutation (adjusted OR, 3.29; 95% CI: 1.06-10.1820; p = 0.039). The gender, birth weight and gestation age of neonates, variant c.211G > A and variant of OATP2 gene were not significant. Conclusions: Neonates with Malay ethnicity and G6PD mutation were at risk for hyperbilirubinemia.
URI: http://ddms.usim.edu.my/handle/123456789/8397
ISSN: 0142-6338
Appears in Collections:Journal of Tropical Pediatrics

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