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dc.contributor.authorR.A., Ramli,-
dc.contributor.authorP., Pudjiastuti,-
dc.contributor.authorT.S., Tjahjandaric,-
dc.contributor.authorW., Lie,-
dc.contributor.authorR., Rattanajak,-
dc.contributor.authorS., Kamchonwongapaisan,-
dc.contributor.authorS.G., Pyne,-
dc.description.abstractTwo new protostemonine-type alkaloids, javastemonine A and B (3 and 4) have been isolated from the root extracts of Stemona javanica together with four known Stemona alkaloids, 13-demethoxy-11(S∗),12(R∗)-dihydroprotostemonine (1), isoprotostemonine (2), protostemonine and isomaistemonine. The structures and relative configurations of the new alkaloids were determined by spectroscopic analysis. The alkaloids 1 and 2 and protostemonine showed moderated antiplasmodial activities against the Plasmodium falciparum strains, TM4 (IC50 values of 17.7 ± 3.7, 16.8 ± 5.4, 16.0 ± 4.2 μg/mL, respectively) and K1 (IC50 values of 16.8 ± 3.1, 14.1 ± 3.7, 11.9 ± 3.3 μg/mL, respectively). These compounds showed no significant cytotoxicities against KB or Vero cells or acetylcholinesterase inhibitory activities.en_US
dc.publisherElsevier Ltden_US
dc.subjectHuman acetylcholinesteraseen_US
dc.subjectJavastemonine A and Ben_US
dc.subjectStemona javanicaen_US
dc.titleAlkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activitiesen_US
Appears in Collections:Phytochemistry Letters

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